
Greenberg currently lives in London, England. Greenberg attended Brighton School of Art, studying illustration. The book A Hundred Billion Trillion Stars with Seth Fishman won the 2018 Mathical Book Prize. Greenberg has also illustrated several children's books. This is a tale, bookended by funerals, about the collision between dreamlike places of possibility and constrained 19th-century lives". James Smart, for The Guardian, wrote: "Greenberg blurs fiction and memoir: characters walk between worlds and woo their creators. In Glass Town (2020), parts of the Brontë juvenilia are retold and intersected with the lives of four Brontë children - Charlotte, Branwell, Emily and Anne, as they explore the paracosm they created. In 2016, Greenberg released her second graphic novel, The One Hundred Nights of Hero. It has been translated into German, Spanish, French and Polish. Rachel Cooke, reviewing her book in The Guardian, said "her wonderful book already feels like a classic" and compared her to Tove Jansson. Greenberg's first graphic novel, The Encyclopedia of Early Earth (2013), is a series of interlinking stories set in Early Earth, where her prize-winning short story was also set.

She entered again in 2011 and won with Love in a Very Cold Climate, a love story about a Nord, a north-pole dweller, and a Suit, a south-pole dweller, who can never touch. Greenberg first entered the prize in 2009, when she came second. The Observer/Cape/Comica Graphic Short Story Prize She has worked with Chatham Dockyard, Tyntesfield House and The Museum of Marco Polo. In 2014, she was a select at Pick Me Up at Somerset House.

An original piece of fiction by Hari Kunzru was transformed into a "walk-in graphic novel". In 2013, she was one of 20 leading graphic designers and illustrators to feature in the Memory Palace exhibition at the V & A, sponsored by Sky Arts. Greenberg has been published in The Guardian, The Observer, The New York Times and Nobrow Press.

Her first book, The Encyclopedia of Early Earth, was published in 2013 by Jonathan Cape in the UK, Little Brown in the US and Random House in Canada. Isabel Greenberg is a British graphic novelist and illustrator.
